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Metronidazole

Ingredient · In our Redness Relief Formula

Metronidazole, applied to the skin

Metronidazole is a long-trusted rosacea cream. It helps calm redness and the inflamed bumps of rosacea.1,2

Abstract coral glass mosaic, illustrative ingredient artwork
Metronidazole

Photos are illustrations, not the medicine. Metronidazole is made in a lab.

FDA-approved ingredient

Metronidazole gel is FDA-approved for the inflammatory lesions of rosacea.1 Ours is combined with other actives. Our creams are compounded by a licensed pharmacy, and compounded versions are not FDA-approved.4

FDA-approved for this useWell studied, used off-labelEarly evidenceLittle or no human data

The studies below used FDA-approved products or other forms. Our compounded version hasn't been studied in trials, and results may differ.

What it is

Metronidazole belongs to a family of medicines called nitroimidazoles. On the skin, it's used for the red bumps of rosacea.1

Why it's in this product

It brings a long safety track record to our Redness Relief Formula, working alongside ivermectin, azelaic acid and niacinamide.

Redness Relief Formula

What the studies in people show

  • Systematic reviewBetter than placeboA Cochrane review found metronidazole more effective than placebo for rosacea bumps. In three trials, doctors were about twice as likely to rate people as improved (moderate-quality evidence).2
  • Randomized trialA useful comparisonIn a trial of 962 people, metronidazole 0.75% cream reduced inflamed bumps by 74% at 16 weeks. Ivermectin did a little better, at 83%.3

What we don't know yet

Most rosacea trials are short, and how long improvements last isn't well reported.2 Our combination cream hasn't been tested as a whole.

Safety, in plain English

Metronidazole gel is generally well tolerated on the skin. The most common side effects reported in trials of the 1% gel were cold-like symptoms and headache, not skin problems.1

A licensed clinician reviews your health history and decides whether this cream is appropriate for you. Exploring it here never means you'll get a prescription.

Curious about metronidazole?

Start with a free assessment. A licensed clinician reviews your health history and decides whether treatment is appropriate. No pressure, and no prescription unless it makes sense for you.

See Redness Relief FormulaHow care works

Sources

  1. U.S. National Library of Medicine, DailyMed. MetroGel (metronidazole) gel, 1%: prescribing information. DailyMed
  2. van Zuuren EJ, et al. Interventions for rosacea. Cochrane Database Syst Rev. 2015;(4):CD003262. PubMed 25919144
  3. Taieb A, et al. Superiority of ivermectin 1% cream over metronidazole 0.75% cream in treating inflammatory lesions of rosacea: a randomized, investigator-blinded trial. Br J Dermatol. 2015;172:1103-1110. PubMed 25228137
  4. U.S. Food and Drug Administration. Compounding and the FDA: Questions and Answers. FDA

Sources checked November 8, 2026. This page is general education, not medical advice, and it doesn't mean any treatment is right for you. Photos: Unsplash (Robert Anderson).