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Sermorelin

Ingredient · In our Sermorelin Injection and Sermorelin Tablet

Sermorelin (GHRH 1-29)

Sermorelin is a lab-made copy of the first part of a hormone your brain uses to tell the pituitary gland to release growth hormone. Instead of replacing growth hormone, it nudges your body to make more of its own.1,2

Abstract teal light helix, illustrative ingredient artwork
Sermorelin

Photos are illustrations, not the medicine. Sermorelin is made in a lab.

Very limited evidence

Sermorelin was once sold as an FDA-approved medicine (Geref) for children with growth hormone problems. It was later discontinued, and FDA determined that wasn't for safety or effectiveness reasons.1,2 It has never been approved for midlife wellness, and the studies in older adults are small. Our sermorelin is compounded by a licensed pharmacy, and compounded versions are not FDA-approved.6

FDA-approved for this useWell studied, used off-labelEarly evidenceLittle or no human data

The studies below used FDA-approved products or other forms. Our compounded version hasn't been studied in trials, and results may differ.

What it is

Growth hormone helps maintain muscle, skin and metabolism, and your body makes less of it as you age. Sermorelin mimics growth hormone-releasing hormone (GHRH), the signal that tells your pituitary gland to release it.2,3

Why it's in these products

The idea is to support the body's own growth hormone rhythm rather than inject growth hormone itself. It's an appealing idea, but the human evidence for midlife benefits is thin, and we'd rather show you exactly what exists.

Sermorelin InjectionSermorelin Tablet

What the studies in people show

  • Small trial, menMore growth hormone, small strength changesEleven healthy men aged 64 to 76 injected sermorelin nightly for 6 weeks. Their nighttime growth hormone rose and two of six strength measures improved, but body composition, blood sugar and cholesterol didn't change. No significant side effects were seen.3
  • Small trial, men and womenDifferent results for womenIn 19 adults aged 55 to 71 (10 women), 16 weeks of a closely related GHRH compound raised IGF-1 (a growth hormone marker) and skin thickness in both sexes. Well-being and libido improved in men but not women, and sleep didn't change in either group.4
  • TabletNo human studies of tabletsWe searched PubMed and found no published human studies of sermorelin taken by mouth as of November 2026.5 The studies that do exist all used injections.

What we don't know yet

Whether sermorelin improves energy, sleep, body composition or skin in women in midlife, the right dose, and long-term safety. The studies above are small, short and mostly in men, so treat any bold promises about sermorelin with a healthy side-eye.

Safety, in plain English

The small studies reported few side effects; one saw a temporary rise in blood fats that settled by the end.3,4 Because sermorelin raises growth hormone, your clinician will consider your personal history, including any history of cancer, before deciding.

A licensed clinician reviews your health history and decides whether it's appropriate for you. Exploring it here never means you'll get a prescription.

Curious about Sermorelin?

Start with a free assessment. A licensed clinician reviews your health history and decides whether treatment is appropriate. No pressure, and no prescription unless it makes sense for you.

See SermorelinHow care works

Sources

  1. Federal Register. Determination that GEREF (sermorelin acetate) injection was not withdrawn from sale for reasons of safety or effectiveness. March 4, 2013. Federal Register
  2. PubChem, National Center for Biotechnology Information. Sermorelin (CID 16132413). PubChem
  3. Vittone J, Blackman MR, Busby-Whitehead J, et al. Effects of single nightly injections of growth hormone-releasing hormone (GHRH 1-29) in healthy elderly men. Metabolism. 1997;46:89-96. PubMed 9005976
  4. Khorram O, Laughlin GA, Yen SS. Endocrine and metabolic effects of long-term administration of [Nle27]growth hormone-releasing hormone-(1-29)-NH2 in age-advanced men and women. J Clin Endocrinol Metab. 1997;82:1472-1479. PubMed 9141536
  5. PubMed search, "sermorelin AND (oral OR sublingual OR tablet OR troche)", run November 8, 2026: 8 results, none a human study of oral sermorelin. PubMed search
  6. U.S. Food and Drug Administration. Compounding and the FDA: Questions and Answers. FDA

Sources checked November 8, 2026. This page is general education, not medical advice, and it doesn't mean any treatment is right for you. Photos: Unsplash (Robert Anderson, Martin Brechtl).