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Niacinamide

Ingredient · In our Midlife Skin Formula, Post-Breakout Acne Cream, Redness Relief Formula, Skin Renewal Formula and Skin Brightening Formula

Niacinamide (vitamin B3)

Niacinamide is a form of vitamin B3 that supports your skin barrier and helps even out tone. It's generally well tolerated.1,2

Abstract pearl interference film, illustrative ingredient artwork
Niacinamide

Photos are illustrations, not the medicine. Niacinamide is made in a lab.

Cosmetic ingredient, small trials

Niacinamide isn't an FDA-approved drug for skin. Its evidence comes from small controlled trials, several run by a skin care company.1,2 Our creams are compounded by a licensed pharmacy, and compounded versions are not FDA-approved.3

FDA-approved for this useWell studied, used off-labelEarly evidenceLittle or no human data

The studies below used FDA-approved products or other forms. Our compounded version hasn't been studied in trials, and results may differ.

What it is

Niacinamide helps limit how much pigment moves from pigment cells into the surrounding skin cells, which can soften dark spots over time.2

Why it's in this product

It plays well with stronger ingredients and helps balance them out, which is why it appears in five of our skin creams.

Midlife Skin FormulaPost-Breakout Acne CreamRedness Relief FormulaSkin Renewal FormulaSkin Brightening Formula

What the studies in people show

  • Randomized trialSmoother, more even skin in 12 weeksIn 50 women with sun-aged skin, 5% niacinamide on one side of the face for 12 weeks reduced fine lines, dark spots, red blotchiness and yellowing compared with a plain cream on the other side.1
  • Controlled trialLess hyperpigmentationIn a paired study of 18 people, a 5% niacinamide moisturizer reduced hyperpigmentation compared with a plain moisturizer after four weeks.2

What we don't know yet

Both studies were small, and their authors worked for Procter & Gamble, which sells niacinamide skin care.1,2 We think they're worth knowing about, and worth reading with that in mind.

Safety, in plain English

Niacinamide was well tolerated in the trials above.1 As with any new cream, tell your clinician if you notice irritation.

A licensed clinician reviews your health history and decides whether this cream is appropriate for you. Exploring it here never means you'll get a prescription.

Curious about niacinamide?

Start with a free assessment. A licensed clinician reviews your health history and decides whether treatment is appropriate. No pressure, and no prescription unless it makes sense for you.

See Midlife Skin FormulaHow care works

Sources

  1. Bissett DL, et al. Niacinamide: a B vitamin that improves aging facial skin appearance. Dermatol Surg. 2005;31:860-865. PubMed 16029679
  2. Hakozaki T, et al. The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer. Br J Dermatol. 2002;147:20-31. PubMed 12100180
  3. U.S. Food and Drug Administration. Compounding and the FDA: Questions and Answers. FDA

Sources checked November 8, 2026. This page is general education, not medical advice, and it doesn't mean any treatment is right for you. Photos: Unsplash (Robert Anderson, Pushpak Dsilva, Jess Bate).