Images are for illustration only. Your medication is prepared and packaged by a licensed pharmacy, so containers, labels and colors will look different.
Midlife Skin Formula
Compounded cream · estriol, niacinamide & tretinoin
$79/mo · $79 billed monthly
Or split it into smaller payments withKlarna.
A formula made for skin that changed with menopause, with a topical estrogen, niacinamide and low-strength tretinoin.
Plan: billed only after a clinician approves you
✓ Free assessment · pay only if prescribed
Start your free assessmentProduct details
A custom formula with estriol, niacinamide and low-strength tretinoin, compounded for you by a licensed pharmacy.
- Once a day
- Made for you
- Monthly refills
- Reviewed by a licensed U.S. clinician
- Free, discreet shipping
Key ingredients
- Estriol
- Niacinamide
- Tretinoin
How to use it
What's included
- A licensed clinician's review of your health history
- Medication, if prescribed
- Monthly check-ins, and dose adjustments when appropriate
- A care team you can text or email, with a response within 24 hours, or call from 9 a.m. to 8 p.m. ET
- Refill reminders and easy plan changes
- Goddess Protocol Plus app membership (coming soon)
Side effects & safety
Based on published research and prescribing information: American Academy of Dermatology: acne guidelines (2024) · The Menopause Society: 2022 Hormone Therapy Position Statement. Your clinician reviews your personal risks before prescribing.
About compounded medications
Prescription required. A licensed clinician decides whether treatment is appropriate, and which medication and dose, if any, is right for you. Exploring options doesn't mean you'll be prescribed. Results vary. Plans renew automatically; cancel anytime at least 48 hours before your next billing date. Prepaid plans are refunded for unused months.
What's inside
For us, ingredients matter
Compounded for you by a licensed pharmacy. Here's what each ingredient is there to do.
Estriol
A gentle estrogen applied to the skin. Small studies suggest it may help skin thickness and hydration after menopause. The evidence is early.
Niacinamide
A form of vitamin B3 that supports your skin barrier and helps even out tone.
Tretinoin
Prescription vitamin A, the most-studied ingredient for fine lines, texture and tone. Start slow.
How to use
How to use it. Simple, every time.
Apply a thin layer to clean, dry skin as directed, usually at night. Start slowly if your skin is sensitive.
How care works ›Feel good. Feel supported.
Licensed clinicians
A clinician builds a formula around your skin.
Rooted in research
Ingredients with real evidence behind them.
Made for midlife skin
Hormonal breakouts, redness and dark spots, all welcome here.
What to expect
Change that builds over time.
- Weeks 1–4
The adjustment phase
Some dryness, flaking or a few extra breakouts can happen as skin adjusts. Start slow and moisturize.
- Weeks 8–12
Early changes
In studies, skin changes usually take two to three months to show. Monthly photos help you see them.
- Month 3+
Review and refine
Your clinician checks in and adjusts the formula or strength if needed.
Timelines are based on these studies. Results vary, and your clinician will tailor the plan to you.
Check-ins every month
Us vs. the usual
Real care. No shortcuts.
Not a rushed seven-minute appointment, and not guessing on your own. Ongoing care from people who get midlife.
| Goddess Protocol Rx | A rushed appointment | Going it alone | |
|---|---|---|---|
| A licensed clinician reviews your history | ✓ | ✓ | |
| Care focused on midlife women | ✓ | ||
| Monthly check-ins and dose adjustments | ✓ | ||
| Text your care team anytime | ✓ | ||
| All-in price, nothing owed unless prescribed | ✓ | ✓ | |
| App, recipes and workouts included | ✓ |
Included with every plan
Everything you need, in one place
Clinician review
A licensed U.S. clinician reviews your health history.
Monthly check-ins
Dose adjustments when appropriate, and refill reminders.
Free shipping
Discreet delivery to your door.
Plus app included
Hespera (your private AI chat), workouts, recipes and sleep stories. Coming soon.
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