Bi-Est Cream: illustrative photo of a pharmacy jar

The Bi-Est Cream jar in an everyday setting

Bi-Est Cream at a glance: what it does and how you use it. Bi-Est combines two forms of estrogen in one cream that's absorbed through the skin. Apply the prescribed amount to clean skin once a day, as directed.

A hand holding the Bi-Est Cream jar, shown at real size

Images are for illustration only. Your medication is prepared and packaged by a licensed pharmacy, so containers, labels and colors will look different.

Menopause

Bi-Est Cream

Estriol + estradiol · topical cream · 3-month supply

$86/mo · $259 billed every 3 months

Or split it into smaller payments withKlarna.

A compounded estrogen cream combining estriol and estradiol, applied to the skin. If you have a uterus, you'll also need a progesterone capsule to protect its lining. A cream can't do that job reliably.

Plan: billed only after a clinician approves you

3-month supply$259 billed every 3 months$86/mo

✓ Free assessment · pay only if prescribed

Start your free assessment

Licensed clinicians

Free, discreet shipping

All-in price

Your care team, on callText or email anytime, reply within 24 hours. Call 9 a.m. to 8 p.m. ET.

Product details

Bi-Est combines two forms of estrogen in one cream that's absorbed through the skin.

Once a day
Applied to skin
3-month supply
Reviewed by a licensed U.S. clinician
Free, discreet shipping

How to use it

Apply the prescribed amount to clean skin once a day, as directed.

What's included

A licensed clinician's review of your health history
Medication, if prescribed
Monthly check-ins, and dose adjustments when appropriate
A care team you can text or email, with a response within 24 hours, or call from 9 a.m. to 8 p.m. ET
Refill reminders and easy plan changes
Goddess Protocol Plus app membership (coming soon)

Side effects & safety

Estrogen isn't right for everyone, including women with certain cancers, blood clots, stroke, liver disease or unexplained bleeding. If you have a uterus, estrogen needs to be paired with progesterone to protect its lining. Your clinician reviews your history, weighs benefits and risks with you, and checks in over time. Bi-Est is compounded, so it isn't FDA-approved, and estriol isn't in any FDA-approved product in the U.S. Major medical groups prefer FDA-approved hormones when one fits, and FDA-approved estradiol is also bioidentical. Your clinician will talk through why one option might suit you better than another.

Based on published research and prescribing information: The Menopause Society: 2022 Hormone Therapy Position Statement. Your clinician reviews your personal risks before prescribing.

About compounded medications

This is a compounded medication, so it isn't FDA-approved. Your clinician can talk you through FDA-approved alternatives.

Often discussed together

Progesterone CapsuleFrom $83/moIf you have a uterus, estrogen is paired with progesterone to protect the uterine lining.

Your clinician decides whether any combination is right for you.

Prescription required. A licensed clinician decides whether treatment is appropriate, and which medication and dose, if any, is right for you. Exploring options doesn't mean you'll be prescribed. Results vary. Plans renew automatically; cancel anytime at least 48 hours before your next billing date. Prepaid plans are refunded for unused months.

Your midlife

Feel like yourself. Again.

Start your free assessment ›

How to use

How to use it. Simple, every time.

Apply the prescribed amount to clean skin once a day, as directed.

How care works ›

Feel good. Feel supported.

01.

Licensed clinicians

Menopause-literate care from real U.S. clinicians.

02.

Rooted in research

Built on The Menopause Society's guidance, explained in plain English.

03.

Whole-woman support

Sleep, mood, strength and the rest of your very full life.

What to expect

Change that builds over time.

Weeks 1–2
Settling in
Your body adjusts to the new routine. Mild breast tenderness, spotting or bloating can happen early and often eases. Message your care team anytime.
Weeks 4–8
Early changes
Many women in studies notice hot flashes and sleep shifting within the first couple of months. Everyone's timeline is different.
Month 3
Check in and adjust
Your clinician reviews how you're feeling and whether the dose or form still fits.

Timelines are based on these studies. Results vary, and your clinician will tailor the plan to you.

Check-ins every month

Us vs. the usual

Real care. No shortcuts.

Not a rushed seven-minute appointment, and not guessing on your own. Ongoing care from people who get midlife.

	Goddess Protocol Rx	A rushed appointment	Going it alone
A licensed clinician reviews your history	✓	✓
Care focused on midlife women	✓
Monthly check-ins and dose adjustments	✓
Text your care team anytime	✓
All-in price, nothing owed unless prescribed	✓		✓
App, recipes and workouts included	✓