Estradiol Patch: illustrative photo of a pharmacy patch
The Estradiol Patch patch in an everyday setting
Estradiol Patch at a glance: what it does and how you use it. The patch delivers a steady amount of estradiol through your skin into your bloodstream, skipping the first pass through the liver. Apply a fresh patch to clean, dry skin on your lower belly or hip, once or twice a week as directed.
A hand holding the Estradiol Patch patch, shown at real size
Close-up of the Estradiol Patch patch

Images are for illustration only. Your medication is prepared and packaged by a licensed pharmacy, so containers, labels and colors will look different.

Menopause

Estradiol Patch

Estradiol · transdermal patch · 3-month supply

Coming soon

Estrogen through the skin, changed once or twice a week. Research suggests skin-delivered estrogen may carry a lower clot risk than pills. Your clinician decides if it fits.

Coming soon

We're finalizing this option with our pharmacy partner. You can start your assessment now, and your clinician will talk through what's available.

Start your free assessment

Not prescribed? You pay nothing.

Licensed clinicians
Free, discreet shipping
All-in price
Your care team, on callText or email anytime, reply within 24 hours. Call 9 a.m. to 8 p.m. ET.
Product details

The patch delivers a steady amount of estradiol through your skin into your bloodstream, skipping the first pass through the liver.

  • Changed 1–2× a week
  • Through the skin
  • 3-month supply
  • Reviewed by a licensed U.S. clinician
  • Free, discreet shipping
How to use it
Apply a fresh patch to clean, dry skin on your lower belly or hip, once or twice a week as directed.
What's included
  • A licensed clinician's review of your health history
  • Medication, if prescribed
  • Monthly check-ins, and dose adjustments when appropriate
  • A care team you can text or email, with a response within 24 hours, or call from 9 a.m. to 8 p.m. ET
  • Refill reminders and easy plan changes
  • Goddess Protocol Plus app membership (coming soon)
Side effects & safety
Estrogen isn't right for everyone, including women with certain cancers, blood clots, stroke, liver disease or unexplained bleeding. If you have a uterus, estrogen needs to be paired with progesterone to protect its lining. Your clinician reviews your history, weighs benefits and risks with you, and checks in over time.

Based on published research and prescribing information: The Menopause Society: 2022 Hormone Therapy Position Statement. Your clinician reviews your personal risks before prescribing.

Prescription required. A licensed clinician decides whether treatment is appropriate, and which medication and dose, if any, is right for you. Exploring options doesn't mean you'll be prescribed. Results vary. Plans renew automatically; cancel anytime at least 48 hours before your next billing date. Prepaid plans are refunded for unused months.

Your midlife

Feel like yourself. Again.

Start your free assessment ›

How to use

How to use it. Simple, every time.

Apply a fresh patch to clean, dry skin on your lower belly or hip, once or twice a week as directed.

How care works ›

Feel good. Feel supported.

01.

Licensed clinicians

Menopause-literate care from real U.S. clinicians.

02.

Rooted in research

Built on The Menopause Society's guidance, explained in plain English.

03.

Whole-woman support

Sleep, mood, strength and the rest of your very full life.

What to expect

Change that builds over time.

  1. Weeks 1–2

    Settling in

    Your body adjusts to the new routine. Mild breast tenderness, spotting or bloating can happen early and often eases. Message your care team anytime.

  2. Weeks 4–8

    Early changes

    Many women in studies notice hot flashes and sleep shifting within the first couple of months. Everyone's timeline is different.

  3. Month 3

    Check in and adjust

    Your clinician reviews how you're feeling and whether the dose or form still fits.

Timelines are based on these studies. Results vary, and your clinician will tailor the plan to you.

  1. MacLennan AH et al. Oral oestrogen and combined oestrogen/progestogen therapy versus placebo for hot flushes. Cochrane Database Syst Rev. 2004
  2. The 2022 Hormone Therapy Position Statement of The North American Menopause Society. Menopause. 2022;29(7):767-794
Check-ins every month

Us vs. the usual

Real care. No shortcuts.

Not a rushed seven-minute appointment, and not guessing on your own. Ongoing care from people who get midlife.

Goddess Protocol RxA rushed appointmentGoing it alone
A licensed clinician reviews your history✓✓
Care focused on midlife women✓
Monthly check-ins and dose adjustments✓
Text your care team anytime✓
All-in price, nothing owed unless prescribed✓✓
App, recipes and workouts included✓

Included with every plan

Everything you need, in one place

Clinician review

A licensed U.S. clinician reviews your health history.

Monthly check-ins

Dose adjustments when appropriate, and refill reminders.

Free shipping

Discreet delivery to your door.

Plus app included

Hespera (your private AI chat), workouts, recipes and sleep stories. Coming soon.

Straight talk, in your inbox

Research, real stories and one manageable next step. Unsubscribe anytime.

Estradiol PatchComing soon
Start