Images are for illustration only. Your medication is prepared and packaged by a licensed pharmacy, so containers, labels and colors will look different.
Estradiol Vaginal Cream
Estradiol · low-dose vaginal cream · 3-month supply
$73/mo · $219 billed every 3 months
Or split it into smaller payments withKlarna.
Dry, sore, or always hunting for a bathroom? A low-dose cream applied locally, and one of the better-studied options in menopause care.
Plan: billed only after a clinician approves you
✓ Free assessment · pay only if prescribed
Start your free assessmentProduct details
A small amount of estrogen, applied where it's needed, can restore moisture and comfort to vaginal and bladder tissue, with very little reaching the rest of the body.
- A few times a week
- Low dose, local
- 3-month supply
- Reviewed by a licensed U.S. clinician
- Free, discreet shipping
How to use it
What's included
- A licensed clinician's review of your health history
- Medication, if prescribed
- Monthly check-ins, and dose adjustments when appropriate
- A care team you can text or email, with a response within 24 hours, or call from 9 a.m. to 8 p.m. ET
- Refill reminders and easy plan changes
- Goddess Protocol Plus app membership (coming soon)
Side effects & safety
Based on published research and prescribing information: The Menopause Society: 2020 Genitourinary Syndrome of Menopause Position Statement · The Menopause Society: 2022 Hormone Therapy Position Statement. Your clinician reviews your personal risks before prescribing.
About compounded medications
Prescription required. A licensed clinician decides whether treatment is appropriate, and which medication and dose, if any, is right for you. Exploring options doesn't mean you'll be prescribed. Results vary. Plans renew automatically; cancel anytime at least 48 hours before your next billing date. Prepaid plans are refunded for unused months.
How to use
How to use it. Simple, every time.
Applied with the included applicator, usually daily at first and then a few times a week, as directed.
How care works ›Feel good. Feel supported.
Licensed clinicians
Menopause-literate care from real U.S. clinicians.
Rooted in research
Built on The Menopause Society's guidance, explained in plain English.
Whole-woman support
Sleep, mood, strength and the rest of your very full life.
What to expect
Change that builds over time.
- Weeks 1–2
Settling in
Your body adjusts to the new routine. Mild breast tenderness, spotting or bloating can happen early and often eases. Message your care team anytime.
- Weeks 4–8
Early changes
Many women in studies notice hot flashes and sleep shifting within the first couple of months. Everyone's timeline is different.
- Month 3
Check in and adjust
Your clinician reviews how you're feeling and whether the dose or form still fits.
Timelines are based on these studies. Results vary, and your clinician will tailor the plan to you.
Check-ins every month
Us vs. the usual
Real care. No shortcuts.
Not a rushed seven-minute appointment, and not guessing on your own. Ongoing care from people who get midlife.
| Goddess Protocol Rx | A rushed appointment | Going it alone | |
|---|---|---|---|
| A licensed clinician reviews your history | ✓ | ✓ | |
| Care focused on midlife women | ✓ | ||
| Monthly check-ins and dose adjustments | ✓ | ||
| Text your care team anytime | ✓ | ||
| All-in price, nothing owed unless prescribed | ✓ | ✓ | |
| App, recipes and workouts included | ✓ |
Included with every plan
Everything you need, in one place
Clinician review
A licensed U.S. clinician reviews your health history.
Monthly check-ins
Dose adjustments when appropriate, and refill reminders.
Free shipping
Discreet delivery to your door.
Plus app included
Hespera (your private AI chat), workouts, recipes and sleep stories. Coming soon.
3-month supply
3-month supply
3-month supplyStraight talk, in your inbox
Research, real stories and one manageable next step. Unsubscribe anytime.